Mark Oldham, PhD

Department:
Radiation Oncology

Division:
Radiation Physics

Physical Address:
Box 3295
DUMC
Durham, NC 27710

Appointment Telephone:
9196680349

Research Interests:
Dr Oldham is Associate Professor in the Department of Radiation Oncology (primary) and Biomedical Engineering (Secondary).  He is the Director of the Optical Biophysics and 3D Dosimetry Lab.  The lab has received NIH R01 funding to develop optical imaging techniques for 3D dosimetry.  The second major research focus is to develop a new optical imaging technique for high-resolution 3D imaging of vascular networks and gene expression in unsectioned tissue samples.  A range of applications are being explored through collaborations with the Dept of Radiobiology (Prof Mark Dewhirst), and Cell Biology (Prof Tim Oliver).  Dr Oldham's other research interests include image-guided-radiation-therapy, including the study of appropriate margin definition, and applications of tomosynthesis.  

Dr Oldham is also the Director of the Radiation Therapy Track of the Duke Medical Physics MS/PhD program.

Publications:
2009 -- Pubmed # 19235375 -- Sakhalkar HS, Adamovics J, Ibbott G, Oldham M. A comprehensive evaluation of the PRESAGE/optical-CT 3D dosimetry system. Med Phys. 2009 Jan;36(1):71-82.

2008 -- Pubmed # 18765891 -- Kim E, Bowsher J, Thomas AS, Sakhalkar H, Dewhirst M, Oldham M. Improving the quantitative accuracy of optical-emission computed tomography by incorporating an attenuation correction: application to HIF1 imaging. Phys Med Biol. 2008 Oct 7;53(19):5371-5383.

2008 -- Pubmed # 18561683 -- Oldham M, Sakhalkar H, Guo P, Adamovics J. An investigation of the accuracy of an IMRT dose distribution using two- and three-dimensional dosimetry techniques. Med Phys. 2008 May;35(5):2072-80.

2008 -- Pubmed # 18465962 -- Oldham M, Sakhalkar H, Oliver T, Allan Johnson G, Dewhirst M. Optical clearing of unsectioned specimens for three-dimensional imaging via optical transmission and emission tomography. J Biomed Opt. 2008 Mar-Apr;13(2):021113.

2008 -- Pubmed # 18293567 -- Sakhalkar HS, Oldham M. Fast, high-resolution 3D dosimetry utilizing a novel optical-CT scanner incorporating tertiary telecentric collimation. Med Phys. 2008 Jan;35(1):101-11.

2007 -- Pubmed # 17879800 -- Godfrey DJ, Ren L, Yan H, Wu Q, Yoo S, Oldham M, Yin FF. Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS). Med Phys. 2007 Aug;34(8):3374-84.

2007 -- Pubmed # 17343484 -- Oldham M, Sakhalkar H, Wang YM, Guo P, Oliver T, Bentley R, Vujaskovic Z, Dewhirst M. Three-dimensional imaging of whole rodent organs using optical computed and emission tomography. J Biomed Opt. 2007 Jan-Feb;12(1):014009.

2007 -- Pubmed # 17404454 -- Sakhalkar HS, Dewhirst M, Oliver T, Cao Y, Oldham M. Functional imaging in bulk tissue specimens using optical emission tomography: fluorescence preservation during optical clearing. Phys Med Biol. 2007 Apr 21;52(8):2035-54.

2006 -- Pubmed # 16618573 -- Godfrey DJ, Yin FF, Oldham M, Yoo S, Willett C. Digital tomosynthesis with an on-board kilovoltage imaging device. Int J Radiat Oncol Biol Phys. 2006 May 1;65(1):8-15.

2006 -- Pubmed # 17089858 -- Guo P, Adamovics J, Oldham M. A practical three-dimensional dosimetry system for radiation therapy. Med Phys. 2006 Oct;33(10):3962-72.

2006 -- Pubmed # 17464369 -- Guo P, Adamovics J, Oldham M. Quality assurance in 3D dosimetry by optical-CT. J Phys. 2006 Dec 1;56(1):191-194.

2006 -- Pubmed # 16752569 -- Guo PY, Adamovics JA, Oldham M. Characterization of a new radiochromic three-dimensional dosimeter. Med Phys. 2006 May;33(5):1338-45.

2006 -- Pubmed # 17460783 -- Oldham M, Guo P, Adamovics J, Sakhalkar H, Wang Z, Yin F. Towards four dimensional (4D) dosimetry for radiation-therapy. J Phys. 2006;56:225-227.

2006 -- Pubmed # 17460782 -- Oldham M, Guo P, Gluckman G, Adamovics J. IMRT verification using a radiochromic/optical-CT dosimetry system. J Phys. 2006;56:221-224.

2006 -- Pubmed # 17464370 -- Oldham M, Sakhalkar H, Guo P. A dual-purpose CCD based micro-optical-CT scanning system. J Phys. 2006 Dec 1;56(1):199-202.

2006 -- Pubmed # 17022212 -- Oldham M, Sakhalkar H, Oliver T, Wang YM, Kirpatrick J, Cao Y, Badea C, Johnson GA, Dewhirst M. Three-dimensional imaging of xenograft tumors using optical computed and emission tomography. Med Phys. 2006 Sep;33(9):3193-202.

2006 -- Pubmed # 17460781 -- Oldham M. 3D dosimetry by optical-CT scanning. J Phys. 2006;56:58-71.

2006 -- Pubmed # 16564444 -- Yin FF, Das S, Kirkpatrick J, Oldham M, Wang Z, Zhou SM. Physics and imaging for targeting of oligometastases. Semin Radiat Oncol. 2006 Apr;16(2):85-101.

2005 -- Pubmed # 15719950 -- Das SK, Baydush AH, Zhou S, Miften M, Yu X, Craciunescu O, Oldham M, Light K, Wong T, Blazing M, Borges-Neto S, Dewhirst MW, Marks LB. Predicting radiotherapy-induced cardiac perfusion defects. Med Phys. 2005 Jan;32(1):19-27.

2005 -- Pubmed # 15890424 -- Létourneau D, Wong JW, Oldham M, Gulam M, Watt L, Jaffray DA, Siewerdsen JH, Martinez AA. Cone-beam-CT guided radiation therapy: technical implementation. Radiother Oncol. 2005 Jun;75(3):279-86.

2005 -- Pubmed # 17235366 -- Oldham M, Kim L, Hugo G. Optical-CT imaging of complex 3D dose distributions. J Phys. 2005 Apr;5745:138-146.

2005 -- Pubmed # 15890419 -- Oldham M, Létourneau D, Watt L, Hugo G, Yan D, Lockman D, Kim LH, Chen PY, Martinez A, Wong JW. Cone-beam-CT guided radiation therapy: A model for on-line application. Radiother Oncol. 2005 Jun;75(3):271.E1-8.

2004 -- Pubmed # 15028408 -- Létourneau D, Gulam M, Yan D, Oldham M, Wong JW. Evaluation of a 2D diode array for IMRT quality assurance. Radiother Oncol. 2004 Feb;70(2):199-206.

2004 -- Pubmed # 15191297 -- Oldham M, Kim L. Optical-CT gel-dosimetry. II: Optical artifacts and geometrical distortion. Med Phys. 2004 May;31(5):1093-104.

2004 -- Pubmed # 17082823 -- Oldham M. Optical-CT scanning of polymer gels. J Phys. 2004;3:122-135.

2003 -- Pubmed # 12722814 -- Oldham M, Siewerdsen JH, Kumar S, Wong J, Jaffray DA. Optical-CT gel-dosimetry I: basic investigations. Med Phys. 2003 Apr;30(4):623-34.

2001 -- Pubmed # 11548936 -- Oldham M, Sapareto SA, Li XA, Allen J, Sutlief S, Wong OC, Wong JW. Practical aspects of in situ 16O (gamma,n) 15O activation using a conventional medical accelerator for the purpose of perfusion imaging. Med Phys. 2001 Aug;28(8):1669-78.

2001 -- Pubmed # 11488576 -- Oldham M, Siewerdsen JH, Shetty A, Jaffray DA. High resolution gel-dosimetry by optical-CT and MR scanning. Med Phys. 2001 Jul;28(7):1436-45.

2000 -- Pubmed # 10795976 -- Baustert IC, Oldham M, Smith TA, Hayes C, Webb S, Leach MO. Optimized MR imaging for polyacrylamide gel dosimetry. Phys Med Biol. 2000 Apr;45(4):847-58.

2000 -- Pubmed # 10984228 -- Low DA, Markman J, Dempsey JF, Mutic S, Oldham M, Venkatesan R, Haacke EM, Purdy JA. Noise in polymer gel measurements using MRI. Med Phys. 2000 Aug;27(8):1814-7.

2000 -- Pubmed # 11064643 -- McJury M, Oldham M, Cosgrove VP, Murphy PS, Doran S, Leach MO, Webb S. Radiation dosimetry using polymer gels: methods and applications. Br J Radiol. 2000 Sep;73(873):919-29.

1999 -- Pubmed # 10435818 -- Bedford JL, Khoo VS, Oldham M, Dearnaley DP, Webb S. A comparison of coplanar four-field techniques for conformal radiotherapy of the prostate. Radiother Oncol. 1999 Jun;51(3):225-35.

1999 -- Pubmed # 10487565 -- Khoo VS, Oldham M, Adams EJ, Bedford JL, Webb S, Brada M. Comparison of intensity-modulated tomotherapy with stereotactically guided conformal radiotherapy for brain tumors. Int J Radiat Oncol Biol Phys. 1999 Sep 1;45(2):415-25.

1999 -- Pubmed # 10473200 -- McJury M, Oldham M, Leach MO, Webb S. Dynamics of polymerization in polyacrylamide gel (PAG) dosimeters: (I) ageing and long-term stability. Phys Med Biol. 1999 Aug;44(8):1863-73.

1999 -- Pubmed # 10533920 -- McJury M, Tapper PD, Cosgrove VP, Murphy PS, Griffin S, Leach MO, Webb S, Oldham M. Experimental 3D dosimetry around a high-dose-rate clinical 192Ir source using a polyacrylamide gel (PAG) dosimeter. Phys Med Biol. 1999 Oct;44(10):2431-44.

1999 -- Pubmed # 10070789 -- Rowbottom CG, Oldham M, Webb S. Constrained customization of non-coplanar beam orientations in radiotherapy of brain tumours. Phys Med Biol. 1999 Feb;44(2):383-99.

1999 -- Pubmed # 10495119 -- Rowbottom CG, Webb S, Oldham M. Beam-orientation customization using an artificial neural network. Phys Med Biol. 1999 Sep;44(9):2251-62.

1999 -- Pubmed # 10078659 -- Rowbottom CG, Webb S, Oldham M. Is it possible to optimize a radiotherapy treatment plan? Int J Radiat Oncol Biol Phys. 1999 Feb 1;43(3):698-9.

1998 -- Pubmed # 10211069 -- Guzel Z, Bedford JL, Childs PJ, Nahum AE, Webb S, Oldham M, Tait D. A comparison of conventional and conformal radiotherapy of the oesophagus: work in progress. Br J Radiol. 1998 Oct;71(850):1076-82.

1998 -- Pubmed # 9623644 -- Oldham M, Baustert I, Lord C, Smith TA, McJury M, Warrington AP, Leach MO, Webb S. An investigation into the dosimetry of a nine-field tomotherapy irradiation using BANG-gel dosimetry. Phys Med Biol. 1998 May;43(5):1113-32.

1998 -- Pubmed # 9725594 -- Oldham M, Khoo VS, Rowbottom CG, Bedford JL, Webb S. A case study comparing the relative benefit of optimizing beam weights, wedge angles, beam orientations and tomotherapy in stereotactic radiotherapy of the brain. Phys Med Biol. 1998 Aug;43(8):2123-46.

1998 -- Pubmed # 9814511 -- Oldham M, McJury M, Baustert IB, Webb S, Leach MO. Improving calibration accuracy in gel dosimetry. Phys Med Biol. 1998 Oct;43(10):2709-20.

1998 -- Pubmed # 9682202 -- Rowbottom CG, Webb S, Oldham M. Improvements in prostate radiotherapy from the customization of beam directions. Med Phys. 1998 Jul;25(7 Pt 1):1171-9.

1997 -- Pubmed # 9245886 -- Bedford JL, Oldham M, Hoess A, Evans PM, Shentall GS, Webb S. Methods for transferring patient and plan data between radiotherapy treatment planning systems. Br J Radiol. 1997 Jul;70(835):740-9.

1997 -- Pubmed # 9198015 -- Oldham M, Webb S. Intensity-modulated radiotherapy by means of static tomotherapy: a planning and verification study. Med Phys. 1997 Jun;24(6):827-36.

1996 -- Pubmed # 8912386 -- Webb S, Oldham M. A method to study the characteristics of 3D dose distributions created by superposition of many intensity-modulated beams delivered via a slit aperture with multiple absorbing vanes. Phys Med Biol. 1996 Oct;41(10):2135-53.

1995 -- Pubmed # 8539454 -- Neal AJ, Oldham M, Dearnaley DP. Comparison of treatment techniques for conformal radiotherapy of the prostate using dose-volume histograms and normal tissue complication probabilities. Radiother Oncol. 1995 Oct;37(1):29-34.

1995 -- Pubmed # 7480829 -- Oldham M, Neal A, Webb S. A comparison of conventional 'forward planning' with inverse planning for 3D conformal radiotherapy of the prostate. Radiother Oncol. 1995 Jun;35(3):248-62.

1995 -- Pubmed # 8746589 -- Oldham M, Neal AJ, Webb S. The optimisation of wedge filters in radiotherapy of the prostate. Radiother Oncol. 1995 Dec;37(3):209-20.

1995 -- Pubmed # 7551787 -- Oldham M, Webb S. The optimization and inherent limitations of 3D conformal radiotherapy treatment plans of the prostate. Br J Radiol. 1995 Aug;68(812):882-93.