We are leaders in the design of drugs to treat oxidative stress injuries such as cancer, radiation injury, CNS injuries (stroke, spinal cord, subarachnoid hemorrhage), lung, eye, whole body, brain and bone marrow radioprotection, diabetes, etc;
All diseases have perturbation of the physiological redox status to some degree, which is described as oxidative stress – very redox-active metal complexes are best suited to restore physiological redox status;
Among metal complexes metalloporphyrin-based redox modulators, known as SOD-mimics, appeared to be the best suited to reduce oxidative stress injuries;
Different metalloporphyrins (metal = Mn, Fe, Zn, Co etc) have been designed, synthesized, and characterized, originally as SOD mimics;
Ability of Mn porphyrins to act as SOD mimics parallels their ability to rescue numerous diseases;
Optimized Mn porpohyrins are cationic compounds bearing quaternized (cationic) meso pyridyl nitrogens;
Optimized Mn porphyrins readily accumulate in mitochondria;
Optimized Mn porphyrins are orally available;
Optimized Mn porphyrin are effective in numerous in vivo models of oxidative stress injuries;
Optimized Mn porphyrins are able to enhance the anticancer radio- and chemotherapy.
Ines Batinic-Haberle, Ph. D.
Department of Radiation Oncology-Cancer Biology
Duke University Medical Center
281b/285 MSRB I, Box 3455
Durham, NC 27710