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Chang Lung Lee, PhD

Assistant Professor in Radiation Oncology
Assistant Professor in Pathology
Office: B220 LSRC Bldg, 308 Research Dr, Box 3813 Med Ctr, Durham, NC 27708
Campus Mail: DUMC Box 3813 Med Ctr, Durham, NC 27708

The overall goal of the Lee lab’s research program is to improve the survivorship of cancer patients by minimizing acute and long-term side effects of radiation therapy. We are also investigating novel medical countermeasures against acute radiation syndrome in the scenarios of nuclear terrorism.

Education and Training

  • Postdoctoral Associate, Radiation Oncology/Kirsch Laboratory, Duke University School of Medicine, 2012 - 2017
  • Ph.D., Duke University, 2012

Publications

Hasapis, Stephanie, Isibel Caraballo, and Chang-Lung Lee. “Transplantation of Unirradiated Bone Marrow Cells after Total-Body Irradiation Prevents the Development of Thymic Lymphoma in Mice through Niche Competition.” Radiat Res 195, no. 3 (March 1, 2021): 301–6. https://doi.org/10.1667/RADE-20-00221.1.

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Sheahan, Breanna J., Ally N. Freeman, Theresa M. Keeley, Linda C. Samuelson, Jatin Roper, Stephanie Hasapis, Chang-Lung Lee, and Christopher M. Dekaney. “Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells.” Cell Mol Gastroenterol Hepatol, February 8, 2021. https://doi.org/10.1016/j.jcmgh.2021.01.015.

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Lee, Chang-Lung, Jessica W. Lee, Andrea R. Daniel, Matt Holbrook, Stephanie Hasapis, Ato O. Wright, Jeremy Brownstein, et al. “Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation.” Radiother Oncol 157 (February 3, 2021): 155–62. https://doi.org/10.1016/j.radonc.2021.01.023.

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Kam, Angel Y. F., Sadhna O. Piryani, Chang-Lung Lee, David A. Rizzieri, Neil L. Spector, Stefanie Sarantopoulos, and Phuong L. Doan. “Selective ERBB2 and BCL2 Inhibition is Synergistic for Mitochondrial-mediated Apoptosis in MDS and AML cells.” Mol Cancer Res, January 29, 2021. https://doi.org/10.1158/1541-7786.MCR-20-0973.

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Daniel, Andrea R., Chang-Lung Lee, Patrick Oh, Lixia Luo, Yan Ma, and David G. Kirsch. “Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain-dependent Manner in Mice.” Health Phys 119, no. 3 (September 2020): 315–21. https://doi.org/10.1097/HP.0000000000001243.

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Tang, Yuning J., Jianguo Huang, Hidetoshi Tsushima, Ga I. Ban, Hongyuan Zhang, Kristianne M. Oristian, Vijitha Puviindran, et al. “Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis.” Cell Rep 28, no. 11 (September 10, 2019): 2837-2850.e5. https://doi.org/10.1016/j.celrep.2019.08.029.

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Lee, Chang-Lung, Andrea R. Daniel, Matt Holbrook, Jeremy Brownstein, Lorraine Da Silva Campos, Stephanie Hasapis, Yan Ma, Luke B. Borst, Cristian T. Badea, and David G. Kirsch. “Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice.” Radiat Res 192, no. 3 (September 2019): 258–66. https://doi.org/10.1667/RR15371.1.

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Lee, Chang-Lung, Yvonne M. Mowery, Andrea R. Daniel, Dadong Zhang, Alexander B. Sibley, Joe R. Delaney, Amy J. Wisdom, et al. “Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.” Jci Insight 4, no. 13 (July 11, 2019). https://doi.org/10.1172/jci.insight.128698.

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Clark, Darin, Matthew Holbrook, Chang-Lung Lee, and Cristian Badea. “Photon-counting cine-cardiac CT in the mouse,” June 4, 2019. https://doi.org/10.1101/660100.

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Torok, Jordan A., Patrick Oh, Katherine D. Castle, Michael Reinsvold, Yan Ma, Lixia Luo, Chang-Lung Lee, and David G. Kirsch. “Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma.” Cancer Res 79, no. 4 (February 15, 2019): 773–82. https://doi.org/10.1158/0008-5472.CAN-17-3103.

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