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David Guy Kirsch, MD, PhD

Barbara Levine University Distinguished Professor
Professor of Radiation Oncology
Professor of Pharmacology and Cancer Biology
Office: LSRC Building, Room B327, Durham, NC 27710
Campus Mail: DUMC Duke Box 91006, Durham, NC 27708

My clinical interests are the multi-modality care of patients with bone and soft tissue sarcomas and developing new sarcoma therapies. My laboratory interests include utilizing mouse models of cancer to study cancer and radiation biology in order to develop new cancer therapies in the pre-clinical setting.

Education and Training

  • Ph.D., Johns Hopkins University School of Medicine, 2000
  • M.D., Johns Hopkins University School of Medicine, 2000

Selected Grants

Publications

Lee, Chang-Lung, Jessica W. Lee, Andrea R. Daniel, Matt Holbrook, Stephanie Hasapis, Ato O. Wright, Jeremy Brownstein, et al. “Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation.” Radiother Oncol 157 (February 3, 2021): 155–62. https://doi.org/10.1016/j.radonc.2021.01.023.

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Salama, Joseph K., Scott R. Floyd, Christopher G. Willett, and David G. Kirsch. “Fostering Radiation Oncology Physician Scientist Trainees Within a Diverse Workforce: The Radiation Oncology Research Scholar Track.” Int J Radiat Oncol Biol Phys, January 4, 2021. https://doi.org/10.1016/j.ijrobp.2020.12.050.

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Deland, Katherine, Bryce F. Starr, Joshua S. Mercer, Jovita Byemerwa, Donna M. Crabtree, Nerissa T. Williams, Lixia Luo, et al. “Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.” J Clin Invest 131, no. 1 (January 4, 2021). https://doi.org/10.1172/JCI142158.

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Wisdom, Amy J., Yvonne M. Mowery, Cierra S. Hong, Jonathon E. Himes, Barzin Y. Nabet, Xiaodi Qin, Dadong Zhang, et al. “Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy.” Nat Commun 11, no. 1 (December 17, 2020): 6410. https://doi.org/10.1038/s41467-020-19917-0.

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Wisdom, Amy J., and David G. Kirsch. “Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.” Cancer Res 80, no. 24 (December 15, 2020): 5459–61. https://doi.org/10.1158/0008-5472.CAN-20-3241.

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Kirsch, David G. “Radiation Therapy as a Treatment for COVID-19?” Int J Radiat Oncol Biol Phys 108, no. 5 (December 1, 2020): 1140–42. https://doi.org/10.1016/j.ijrobp.2020.07.025.

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Prasanna, Pataje G., Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, et al. “Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?” Radiation Research 194, no. 5 (November 2020): 452–64. https://doi.org/10.1667/rade-20-00211.1.

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Lee, Jessica W., Diana M. Cardona, Dan G. Blazer, and David G. Kirsch. “Response to Central Boost Radiation Therapy in an Unresectable Retroperitoneal Sarcoma: A Case Report.” Adv Radiat Oncol 5, no. 6 (November 2020): 1375–79. https://doi.org/10.1016/j.adro.2020.05.012.

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Liu, Shiyu, Ziwei Dai, Daniel E. Cooper, David G. Kirsch, and Jason W. Locasale. “Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle.” Cell Metab 32, no. 4 (October 6, 2020): 619-628.e21. https://doi.org/10.1016/j.cmet.2020.09.005.

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Huang, Jianguo, Mohit Sachdeva, Eric Xu, Timothy J. Robinson, Lixia Luo, Yan Ma, Nerissa T. Williams, et al. “The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways.” Mol Cancer Res 18, no. 10 (October 2020): 1534–44. https://doi.org/10.1158/1541-7786.MCR-19-1170.

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