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Ines Batinic-Haberle, PhD

Professor Emeritus of Radiation Oncology
Office: Rm 285/281B Msrb1, Research Drive, Durham, NC 27710
Campus Mail: DUMC Box 3455 Med Ctr, Durham, NC 27710

Education and Training

  • Research Associate, Chemistry, Duke University, 1992 - 1995
  • Ph.D., University of Zagreb (Croatia), 1988

Publications

Boss, Mary-Keara, Rebecca E. Oberley-Deegan, Ines Batinic-Haberle, Geoffrey A. Talmon, Jason A. Somarelli, Shengnan Xu, Elizabeth A. Kosmacek, et al. “Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models.” Radiat Res 195, no. 2 (February 1, 2021): 128–39. https://doi.org/10.1667/RADE-20-00109.1.

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Tovmasyan, Artak, Ines Batinic-Haberle, and Ludmil Benov. “Antibacterial Activity of Synthetic Cationic Iron Porphyrins.” Antioxidants (Basel) 9, no. 10 (October 10, 2020). https://doi.org/10.3390/antiox9100972.

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Thamilarasan, Madhan, Rodolfo Estupinan, Ines Batinic-Haberle, and Rahima Zennadi. “Mn porphyrins as a novel treatment targeting sickle cell NOXs to reverse and prevent acute vaso-occlusion in vivo.” Blood Adv 4, no. 11 (June 9, 2020): 2372–86. https://doi.org/10.1182/bloodadvances.2020001642.

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Li, Litao, Artak Tovmasyan, Huaxin Sheng, Bin Xu, Romulo S. Sampaio, Julio S. Reboucas, David S. Warner, Ines Batinic-Haberle, and Ivan Spasojevic. “Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP4+, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H2O)MnTnHex-2-PyP5+.” Antioxidants (Basel) 9, no. 6 (June 1, 2020). https://doi.org/10.3390/antiox9060467.

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Olson, Kenneth R., Yan Gao, Andrea K. Steiger, Michael D. Pluth, Charles R. Tessier, Troy A. Markel, David Boone, Robert V. Stahelin, Ines Batinic-Haberle, and Karl D. Straubg. “Effects of Manganese Porphyrins on Cellular Sulfur Metabolism.” Molecules 25, no. 4 (February 22, 2020). https://doi.org/10.3390/molecules25040980.

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Barbosa, Andrezza M., José F. Sarmento-Neto, José E. R. Menezes Filho, Itamar C. G. Jesus, Diego S. Souza, Valério M. N. Vasconcelos, Fagner D. L. Gomes, et al. “Redox-Active Drug, MnTE-2-PyP5+, Prevents and Treats Cardiac Arrhythmias Preserving Heart Contractile Function.” Oxid Med Cell Longev 2020 (2020): 4850697. https://doi.org/10.1155/2020/4850697.

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Olson, Kenneth R., Yan Gao, Faihaan Arif, Shivali Patel, Xiaotong Yuan, Varun Mannam, Scott Howard, et al. “Manganese Porphyrin-Based SOD Mimetics Produce Polysulfides from Hydrogen Sulfide.” Antioxidants (Basel) 8, no. 12 (December 12, 2019). https://doi.org/10.3390/antiox8120639.

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Batinic-Haberle, I., and I. Spasojevic. “25 years of development of Mn porphyrins-from mimics of superoxide dismutase enzymes to thiol signaling to clinical trials: The story of our life in the USA.” Journal of Porphyrins and Phthalocyanines 23, no. 11–12 (November 1, 2019): 1326–35. https://doi.org/10.1142/S1088424619300283.

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Costa, João G., Nuno Saraiva, Ines Batinic-Haberle, Matilde Castro, Nuno G. Oliveira, and Ana S. Fernandes. “The SOD Mimic MnTnHex-2-PyP5+ Reduces the Viability and Migration of 786-O Human Renal Cancer Cells.” Antioxidants (Basel) 8, no. 10 (October 17, 2019). https://doi.org/10.3390/antiox8100490.

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MacKinney, Anson, Emily Woska, Ivan Spasojevic, Ines Batinic-Haberle, and Rahima Zennadi. “Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion.” Redox Biol 25 (July 2019): 101097. https://doi.org/10.1016/j.redox.2019.101097.

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