My clinical interests are the multi-modality care of patients with bone and soft tissue sarcomas and developing new sarcoma therapies. My laboratory interests include utilizing mouse models of cancer to study cancer and radiation biology in order to develop new cancer therapies in the pre-clinical setting
Radiation and Cancer Biology
Radiation Oncology’s Division of Cancer Biology includes outstanding researchers who are pushing forward the frontiers of research in cancer. Their laboratories are involved in tumor angiogenesis and blood flow research, tumor response to hyperthermia, tumor suppressor genes, genomic imprinting in cancer, cell immortalization and telomerase, secondary messengers, gene therapy, and heat sensitive liposomes. The Cancer Biology Division offers many opportunities for translational research and hosts graduate students, post graduate fellows, and medical students seeking research opportunities.
Developed the first conformal high energy animal model of prostate radiotherapy
Developing quantitative optical imaging methods for assessing tumor physiology and hemodynamics
Our lab focuses on studying mechanisms of DNA damage signaling and repair in human and other mammalian cells. Acquiring deeper knowledge on how cancer cells repair DNA damage, or lack of such capabilities thereof, can lead to improved cancer treatments in the clinic.
My lab utilizes sophisticated mouse models to study critical signaling pathways that regulate normal tissue radiation injury and understand how dysregulation of these pathways contributes to the development of radiation-induced cancer.