Kirsch Lab

The Kirsch Lab uses sophisticated genetically engineered mouse models, cellular and molecular biology and biochemistry to study cancer and radiation biology. Our research ranges from fundamental basic questions into the mechanisms by which tumor suppressor genes prevent cancer to translational projects that focus on mechanisms of metastasis, tumor response to radiation therapy and normal tissue injury from radiation. In a collaborative environment, we work together to make discoveries and strive to translate our research into clinical trials for patients with cancer.

David Kirsch MD, PhD, is the Barbara Levine University Professor at Duke. As a physician-scientist, he cares for bone and soft tissue sarcoma patients with radiation therapy in the Duke Cancer Institute. His research program spans the continuum from basic cancer research, to translational radiation biology, to clinical trials, such as SU2C-SARC032 that is testing the combination of immunotherapy and radiation therapy for high risk extremity sarcoma. His lab research is supported by an R35 Outstanding Investigator Award from the National Cancer Institute, grants from the National Institute of Allergy and Infectious Disease and the Department of Defense, as well as several philanthropic organizations including StandUp2Cancer, the Gilbert Family Foundation, the Slifka Foundation and the Leon Levine Foundation. Follow Dr. Kirsch on Twitter here

Mentored Physician Scientists

Zach Reitman, MD, PhD, is a physician-scientist at Duke. As a physician, he provides radiation oncology care for patients with brain tumors at the Duke Cancer Institute. As a scientist, Dr. Reitman and his team work to understand the molecular genetics of brain tumors in order to develop new treatment strategies that are more effective and have fewer side effects. Their goal is to make discoveries that can be translated into clinical trials for patients with brain tumors. Dr. Reitman’s research program is based within the Kirsch Lab in the Duke Department of Radiation Oncology. There, Dr. Reitman and his team leverage the expertise of the Kirsch Lab in radiation biology and in genetically engineered mouse models of cancer. Dr. Reitman also works closely with the faculty and staff in the Preston Robert Tisch Brain Tumor Center at Duke for both his clinical and research work. This research program is supported by part of a Duke Brain Tumor SPORE grant from the National Cancer Institute, and by cancer research foundations including the Pediatric Brain Tumor Foundation, the Michael Mosier Defeat DIPG Foundation, the ChadTough Foundation and the SoSo Strong Foundation.


Mailing Address

Kirsch Lab
Duke University Medical Center
DUMC Box 91006
Durham, NC 27708

Shipping Address

450 Research Drive
LSRC Bldg, Room B324
Durham, NC 27708