Publications
Van Mater D, Xu E, Reddy A, Añó L, Sachdeva M, Huang W, Williams N, Ma Y, Love C, Happ L, Dave S, Kirsch DG. Injury promotes sarcoma development in a genetically and temporally restricted manner. JCI Insight. 2018 Oct 18;3(20) doi: 10.1172/jci.insight.123687. [Epub ahead of print]. PMID:30333301
Torok JA, Oh P, Castle KD, Reinsvold M, Ma Y, Luo L, Lee CL, Kirsch DG. Deletion of ATM in tumor but not endothelial cells improves radiation response in a primary mouse model of lung adenocarcinoma. Cancer Research. 2018 Oct 12. doi: 10.1158/0008-5472.CAN-17-3103. PMID:30315114
Brownstein JM, Wisdom AJ, Castle KD, Mowery YM, Guida P, Lee CL, Tommasino F, Tessa CL, Scifoni E, Gao J, Luo L, Campos LDS, Ma Y, Williams N, Jung SH, Durante M, Kirsch DG. Characterizing the potency and impact of carbon ion therapy in a primary mouse model of soft tissue sarcoma. Molecular Cancer Therapuetics. 2018 Apr;17(4):858-868. PMCID:PMC5912881
Huang J, Chen M, Whitley MJ, Kuo HC, Xu ES, Walens A, Mowery YM, Van Mater D, Eward WC, Cardona DM, Luo L, Ma Y, Lopez OM, Nelson CE, Robinson-Hamm JN, Reddy A, Dave SS, Gersbach CA, Dodd RD, Kirsch DG. Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma. Nature Communications. 2017 Jul 10;8:15999. PMCID:PMC5508130
Dodd RD, Lee CL, Overton T, Huang W, Eward WC, Luo L, Ma Y, Ingram DR, Torres KE, Cardona D, Lazar AJ, Kirsch DG. NF1+/- Hematopoietic cells accelerate malignant peripheral nerve sheath tumor development without altering chemotherapy response. Cancer Research. 2017 Aug 15;77(16):4486-4497. PMCID:PMC5839126
Sachdeva M, Mito JK, Lee CL, Zhang M, Li Z, Dodd RD, Cason D, Luo L, Ma Y, Van Mater D, Gladdy R, Lev DC, Cardona DM, Kirsch DG. MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. Journal of Clinical Investigation. 2014 Oct 1; 124(10):4305-4319. PMCID:PMC4191039
Whitley MJ, Cardona DM, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG 3rd, Hwang SE, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, O’Reilly EK, Riedel RF, Eward WC, Strasfeld DB, Fukumura D, Jain RK, Lee WD, Griffith LG, Bawendi MG, Kirsch DG*^, Brigman BE*.A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. Science Translational Medicine. 2016 Jan 6; 8(320): 320ra4. PMCID:PMC4794335 *co-senior authors, ^corresponding author
Lee CL, Castle KD, Moding EJ, Blum JM, Williams N, Luo L, Ma Y, Borst L, Kim Y, Kirsch DG. Acute DNA damage activates the tumor suppressor p53 to promote radiation-induced lymphoma. Nature Communications. 2015 Sep 24;6:8477. PMCID:PMC4586051
Dodd RD, Sachdeva M, Mito JK, Eward WC, Brigman BE, Ma Y, Dodd L, Kim Y, Lev D, Kirsch DG. Myogenic transcription factors regulate pro-metastatic miR-182. Oncogene. 2016 Apr 7;35(14):1868-1875.PMCID:PMC4523886
Moding EJ, Castle KD, Perez BA, Oh P, Min HD, Norris H, Ma Y, Cardona DM, Lee CL, Kirsch DG. Tumor Cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy. Science Translational Medicine. 2015 Mar 11;7(278): 278ra34. PMCID:PMC4360135
Van Mater D, Añó L, Blum JM, Webster MT, Huang W, Williams N, Ma Y, Cardona DM, Fan CM, Kirsch DG. Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway. Cancer Research. 2015 Feb 1;75(3):605-14. PMCID:PMC4327867
Sachdeva M, Mito JK, Lee CL, Zhang M, Li Z, Dodd RD, Cason D, Luo L, Ma Y, Van Mater D, Gladdy R, Lev DC, Cardona DM, Kirsch DG. MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. Journal of Clinical Investigation. 2014 Oct 1; 124(10):4305-4319. PMCID:PMC4191039
Moding EJ, Lee CL, Castle KD, Oh P, Mao L, Zha S, Min HD, Ma Y, Das S, Kirsch DG. ATM deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. Journal of Clinical Investigation. 2014 Aug 1; 124(8):3325-38. PMCID:PMC4109553
Lee CL, Moding EJ, Kirsch DG. Reining in radiation injury: HIF2α in the gut. Science Translational Medicine. 2014 May 14;6(236):236fs20.doi:10.1126/scitranslmed.3009155. PMID:24828075
Blum JM, Añó L, Li Z, Van Mater D, Bennett BD, Sachdeva M, Lagutina I, Zhang M, Mito JK, Dodd LG, Cardona DM, Dodd RD, Williams N, Ma Y, Lepper C, Linardic CM, Mukherjee S, Grosveld GC, Fan CM, Kirsch DG. Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. Cell Reports. 2013 Nov 27; 5(4):933-940. PMCID: PMC3893104
Lee CL, Moding EJ, Cuneo KC, Li Y, Sullivan JM, Mao L, Washington I, Jeffords LB, Rodrigues RC, Ma Y, Das S, Kontos CD, Kim Y, Rockman HA, Kirsch DG. p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice. Science Signaling. 2012 Jul 24; 5(234). PMCID:PMC3533440