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Featured Publications

Radiation-induced carcinogenesis

  1. Lee CL, Castle KD, Moding EJ, Blum JM, Williams N, Luo L, Ma Y, Borst L, Kim Y, Kirsch DG. Acute DNA Damage Activates the Tumor Suppressor p53 to Promote Radiation-induced Lymphoma. Nature Communications. 2015 Sep 24;6:8477. PMCID: PMC4586051
  2. Moding EJ, Min HD, Castle KD, Ali M, Woodlief L, Williams N, Ma Y, Kim Y, Lee CL, Kirsch DG. An Extra Copy of p53 Suppresses Development of Spontaneous Kras-driven but not Radiation-Induced Cancer. JCI Insight. 2016 Jul 7;1(10). pii:e86698. PMCID:PMC4955525
  3. Lee CL*, Mowery YM*, Daniel AR*, Zhang D, Sibley AB, Delaney JR, Wisdom AJ, Qin X, Wang X, Caraballo I, Gresham J, Luo L, Van Mater D, Owzar K, Kirsch DG. Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma. JCI Insight. 2019 May 21;5. pii: 128698. doi: 10.1172/jci.insight.128698. PubMed PMID: 31112524. (*Equal contribution)
  4. Hasapis S, Caraballo I, Lee CL. Transplantation of unirradiated bone marrow cells following total-body irradiation prevents the development of thymic lymphoma in mice through niche competition. Radiation Research. 2020 in press.

Normal tissue radiation injury

  1. Lee CL, Moding EJ, Cuneo KC, Li Y, Sullivan JM, Mao L, Washington I, Jeffords LB, Rodrigues RC, Ma Y, Das S, Kontos CD, Kim Y, Rockman HA, Kirsch DG.  p53 Functions in Endothelial Cells to Prevent Radiation-Induced Myocardial Injury in Mice. Science Signaling. 2012 Jul 24; 5(234). PMCID: PMC3533440
  2. Lee CL, Min H, Befera N, Clark D, Qi Y, Das S, Johnson GA, Badea CT, Kirsch DG. Assessing Cardiac Injury in Mice with Dual Energy-microCT, 4D-microCT, and microSPECT Imaging After Partial Heart Irradiation. International Journal of Radiation Oncology, Biology, Physics. 2014 Mar 1;88(3):686-693. PMCID: PMC3985387 
  3. Lee CL*, Lento WE*, Castle KD, Chao NJ, Kirsch DG. Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in Mice. Radiation Research. 2014 May; 181(5):445-451. PMCID: PMC4080719 (*Equal contribution)
  4. Lee CL, Oh P, Xu E, Ma Y, Kim Y, Daniel AR, Kirsch DG. Blocking cyclin-dependent kinase 4/6 during single dose vs. fractionated radiation therapy leads to opposite effects on acute gastrointestinal toxicity in mice. International Journal of Radiation Oncology, Biology, Physics. 2018 Jul 26. pii: S0360-3016(18)31645-6. doi: 10.1016/j.ijrobp.2018.07.192. [Epub ahead of print] PubMed PMID: 30056081
  5. Lee CL, Daniel AR, Holbrook M, Brownstein J, Silva Campos LD, Hasapis S, Ma Y, Borst LB, Badea CT, Kirsch DG. Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice. Radiation Research. 2019 Sep;192(3):258-266. doi: 10.1667/RR15371.1. Epub 2019 Jul 2. PubMed PMID: 31265788.

Tumor responses to radiation therapy

  1. Lee CL*, Moding EJ*, Huang X, Li Y, Woodlief LZ, Rodrigues RC, Ma Y, Kirsch DG. Generation of Primary Tumors with Flp Recombinase in FRT-flanked p53 Mice. Disease, Models, and Mechanisms. 2012 May; 5(3):397-402. PMCID: PMC3339833 (*Equal contribution)
  2. Moding EJ, Lee CL, Castle KD, Oh P, Mao L, Zha S, Min HD, Ma Y, Das S, Kirsch DG. ATM Deletion with Dual Recombinase Technology Preferentially Radiosensitizes Tumor Endothelium. Journal of Clinical Investigation. 2014 Aug 1; 124(8):3325-38. PMCID: PMC4109553
  3. Moding EJ, Castle KD, Perez BA, Oh P, Min HD, Norris H, Ma Y, Cardona DM, Lee CL, Kirsch DG. Tumor Cells, but not Endothelial Cells, Mediate Eradication of Primary Sarcomas by Stereotactic Body Radiation Therapy. Science Translational Medicine. 2015 Mar 11;7(278): 278ra34. PMCID: PMC4360135
  4. Torok JA, Oh P, Castle KD, Reinsvold M, Ma Y, Luo L, Kuo HC, Lee CL, Kirsch DG. Atm deletion in tumor but not endothelial cells improves radiation response in a primary mouse model of lung adenocarcinoma. Cancer Research. 2018 Oct 12. pii: canres.3103.2017. doi: 10.1158/0008-5472.CAN-17-3103. [Epub ahead of print] PubMed PMID: 30315114.


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