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The Duke 3D Dosimetry Lab has received NIH R01 funding to develop optical imaging techniques for 3D dosimetry. Our research has demonstrated that a new PRESAGE/optical-CT system is a viable 3D dosimetry system for radiation therapy and general radiation measurement. Our research involves a strong 3-party consortium to pursue two major aims; a continued technical and investigational aim, and a new clinical applications aim. The consortium combines outstanding expertise in 3D dosimetry (Duke) with credentialing experience (Geoff Ibbott at the RPC), and materials expertise (John Adamovics at Rider University). The aims balance investigating innovations to facilitate 3D dosimetry for the non-specialized clinic, while still addressing the urgent need for detailed clinical IMRT dosimetry studies using a more specialized system.

We hypothesize novel optical-CT scanning systems, and novel radiochromic formulations will achieve substantial increase in speed and practicality without compromising accuracy. We also hypothesize that 3D dosimetry techniques will detect more clinical IMRT deliveries failing standard comparison metrics, than conventional 2D techniques. This research will conduct the first comprehensive 3D investigations of the accuracy of IMRT deliveries in cohorts of patients in key clinical sites (pelvic, head-and-neck, and thorax). Successful completion will elevate the state-of-the-art for verification of advanced radiation treatments, and may demonstrate the feasibility of a powerful and comprehensive new 3D credentialing technology with potential to elevate the standard of practice in clinical trials.

The lab has access to ~600sq feet of lab-space in the department of Radiation Therapy Physics. This space includes a dedicated imaging room with dark-room facilities, and a fume hood. The lab contains several unique optical-CT scanning systems, developed in-house, for various applications in 3D dosimetry and biological imaging. We are open to collaborations with other researchers interested in 3D dosimetry, or high-resolution 3D imaging of fluorescent tissue markers.