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Clinical Trials

Duke Radiation Oncology’s coordinated team approach provides patients with sophisticated radiotherapy treatment planning and delivery.

From the administrative staff to your attending physician, we want your relationship with Duke to be as professional, courteous and successful as possible. Our Clinical Research Office combines cutting edge research with compassionate care. As a leading research institution, Duke Radiation Oncology fields numerous clinical trials across all cancer sites.

The research trials conducted by our faculty include radiation therapy, radiation therapy combined with chemotherapy agents, devices, imaging studies, supportive care, quality of life and tissue/blood sampling research. Clinical trials are vital in the development and approval of new therapies. Ask your doctor about clinical trial options in Radiation Oncology that could be available for you.

 

Current Clinical Trials: 

Breast Cancer

Preoperative Single-Fraction Radiotherapy in Early Stage Breast Cancer
Duke Principal Investigator: Dr. Janet Horton

Study of Preoperative Boost Radiotherapy
Duke Principal Investigator: Dr. Janet Horton

Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery
Duke Principal Investigator: Dr. Rachel Blitzblau

Stereotactic Radiosurgery in Treating Patients With Metastatic Breast Cancer, Non-Small Cell Lung Cancer or Prostate Cancer
Duke Principal Investigator: Dr. Joseph Salama

Gastrointestinal Cancer

Pembrolizumab, Radiotherapy and Chemotherapy in Neoadjuvant Treatment of Malignant Esophago-gastric Diseases (PROCEED)
Duke Principal Investigator: Dr. Manisha Palta

Phase II Randomized Trial Comparing Percutaneous Ablation to Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-Surgical Hepatocellular Carcinoma Patients (PROVE-HCC)
Duke Principal Investigator: Dr. Manisha Palta

Gynecological Cancer

No current clinical trials.

Head and Neck Cancer

A Phase 1a-b Trial of Concurrent Radiation Therapy, Cisplatin and BMX-001 in Locally Advanced Head and Neck Cancer
Duke Principal Investigator: Dr. David Brizel

Imaging Studies

Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers (Adaptive PET II)
Duke Principal Investigator: Dr. Junzo Chino

Lung Cancer

Stereotactic Radiosurgery in Treating Patients With Metastatic Breast Cancer, Non-Small Cell Lung Cancer or Prostate Cancer
Duke Principal Investigator: Dr. Joseph Salama

A Study Evaluating the Efficacy and Tolerability of Veliparib in Combination With Paclitaxel/Carboplatin-Based Chemoradiotherapy Followed by Veliparib and Paclitaxel/Carboplatin Consolidation in Subjects With Stage III Non-Small Cell Lung Cancer
Duke Principal Investigator: Dr. Joseph Salama

Phase II Study of Accelerated and Adaptive Radiation Therapy for Locally-Advanced Non-Small Cell Lung Cancer (NSCLC)
Duke Principal Investigator: Dr. Christopher Kelsey

Lymphoma

No current clinical trials.

Prostate Cancer

Stereotactic Radiosurgery in Treating Patients With Metastatic Breast Cancer, Non-Small Cell Lung Cancer or Prostate Cancer
Duke Principal Investigator: Dr. Joseph Salama

Phase II-III Trial of Adjuvant Radiotherapy Following Radical Prostatectomy With or Without Adjuvant Docetaxel
Duke Principal Investigator: Dr. William R. Lee

Quality of Life Studies

PaRTNer: Patient Reported Outcomes and Financial Toxicity in Head and Neck Cancer: A Pilot, Survey-Based Study
Duke Principal Investigator: Dr. Yvonne Mowery

Sarcoma

Phase I/II Trial of Pre-Operative Image Guided Intensity Modulated Proton Radiation Therapy (IMPT) or Photon (IMRT) With Simultaneously Integrated Boost to the High Risk Margin for Retroperitoneal Sarcomas
Duke Principal Investigator: Dr. Dan (Trey) Blazer

Stereotactic Radiosurgery

Outcome in Patients With 4 or More Brain Metastases Treated With Single-Isocenter, Multi-Target (SIMT) Stereotactic Radiosurgery: A Prospective Single-Arm Study in Adults With Brain Metastases
Duke Principal Investigator: Dr. Grace Kim