Clinical Trials

Duke Radiation Oncology’s coordinated team approach provides patients with sophisticated radiotherapy treatment planning and delivery.

From the administrative staff to your attending physician, we want your relationship with Duke to be as professional, courteous and successful as possible. Our clinical research office combines cutting edge research with compassionate care. As a leading research institution, Duke Radiation Oncology fields numerous clinical trials across all cancer sites.

The research trials conducted by our faculty include radiation therapy, radiation therapy combined with chemotherapy agents, devices, imaging studies, supportive care, quality of life and tissue/blood sampling research. Clinical trials are vital in the development and approval of new therapies. Ask your doctor about clinical trial options in radiation oncology that could be available for you.

Current Clinical Trials

Circulating Biomarkers Repository in Adults Diagnosed With Primary and Metastatic Brain Tumors
e110602 Biorepository for Circulating Biomarkers in Brain Tumors
Duke Principal Investigators: Dr. Scott Floyd and Dr. Zach Reitman

Quantitative MRI for Functional Assessment Following SBRT for Spinal Metastases
e103960 SBRT Spine MRI
Duke Principal Investigator: Dr. Scott Floyd

MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases
e103163 SRS Delayed MRI
Duke Principal Investigator: Dr. Scott Floyd

Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx
e105899 H/N PET Dose De-escalation
Duke Principal Investigator: Dr. David Brizel

Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
e89619 Adaptive PET II
Duke Principal Investigator: Dr. Junzo Chino

Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients
e89525 PROVE-HCC
Duke Principal Investigator: Dr. Manisha Palta

Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial
e108295 NRG-GU009
Duke Principal Investigators: Drs. Matthew Boyer and Ryan Fecteau

Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score
e113621 NRG-GU010
Duke Principal Investigator: Dr. Matthew Boyer

Groningen International Study on Sentinel Nodes in Vulvar Cancer-III (GROINSS-VIII)
e109439 NRG-GY024 Vulvar Cancer

Trans-Rectal Ultrasound of the Female Pelvis for Real-Time MRI-US Fusion Based Needle Tracking (TRUS)
 e113768 TRUS
Duke Principal Investigator: Dr. Diandra Ayala-Peacock

Role of Ablative Radiotherapy in the Management of Metastatic Disease: A Patient Data Registry
e103137 Oligomets – Registry Study
Duke Principal Investigator: Dr. Joseph Salama

Modeling Organ Motion During Abdominal Imaging in Healthy Volunteers
e111970 Study and Modeling of Organ Motion during Abdominal Imaging - Healthy Volunteers
Duke Principal Investigators: Deshan Yang, PhD, and John Ginn, PhD