Clinical Trials

Duke Radiation Oncology’s coordinated team approach provides patients with sophisticated radiotherapy treatment planning and delivery.

From the administrative staff to your attending physician, we want your relationship with Duke to be as professional, courteous and successful as possible. Our Clinical Research Office combines cutting edge research with compassionate care. As a leading research institution, Duke Radiation Oncology fields numerous clinical trials across all cancer sites.

The research trials conducted by our faculty include radiation therapy, radiation therapy combined with chemotherapy agents, devices, imaging studies, supportive care, quality of life and tissue/blood sampling research. Clinical trials are vital in the development and approval of new therapies. Ask your doctor about clinical trial options in Radiation Oncology that could be available for you.

Current Clinical Trials: 

Patient-Derived Organoids for Rectal Cancer
Duke Principal Investigator: Dr. Brian Czito

A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer (COMPPARE)
Duke Principal Investigator: Dr. W. Robert Lee

Quantitative MRI for Functional Assessment Following SBRT for Spinal Metastases
Duke Principal Investigator: Dr. Scott Floyd

Role of Ablative Radiotherapy in the Management of Metastatic Disease: A Patient Data Registry
Duke Principal Investigator: Dr. Joseph Salama

Preoperative Single-Fraction Radiotherapy in Early Stage Breast Cancer
Duke Principal Investigator: Dr. Rachel Blitzblau 

Pembrolizumab, Radiotherapy and Chemotherapy in Neoadjuvant Treatment of Malignant Esophago-gastric Diseases (PROCEED)
Duke Principal Investigator: Dr. Manisha Palta

Trial Comparing PLA to HIGRT (PROVE-HCC): A Study for People with Liver Cancer
Duke Principal Investigator: Dr. Manisha Palta

A Trial for Treatment of Cancer Patients With Multiple Brain Metastases Undergoing Whole-Brain Radiotherapy
Duke Principal Investigator: Dr. John Kirkpatrick

Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
Duke Principal Investigator: Dr. Junzo Chino

Phase 2b Study of GC4711 in Combination With SBRT for Nonmetastatic Pancreatic Cancer
Duke Principal Investigator: Dr. Manisha Palta

Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx
Duke Principal Investigator: Dr. David Brizel

Proton or Photon RT for Retroperitoneal Sarcomas
Duke Principal Investigator: Dr. Dan Blazer III

Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma (DLBCL)
Duke Principal Investigator: Dr. Christopher Kelsey

MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases
Duke Principal Investigator: Dr. Scott Floyd

Phase 1/2 Study of SBRT With or Without GC4711 for NSCLC
Duke Principal Investigator: Dr. Christopher Kelsey

Stereotactic Body Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Stage IIA-B Prostate Cancer
Duke Principal Investigator: Dr. John Nelson