From the administrative staff to your attending physician, we want your relationship with Duke to be as professional, courteous and successful as possible. Our Clinical Research Office combines cutting edge research with compassionate care. As a leading research institution, Duke Radiation Oncology fields numerous clinical trials across all cancer sites.
The research trials conducted by our faculty include radiation therapy, radiation therapy combined with chemotherapy agents, devices, imaging studies, supportive care, quality of life and tissue/blood sampling research. Clinical trials are vital in the development and approval of new therapies. Ask your doctor about clinical trial options in Radiation Oncology that could be available for you.
Current Clinical Trials:
Circulating Biomarkers Repository in Adults Diagnosed With Primary and Metastatic Brain Tumors
e110602 Biorepository for Circulating Biomarkers in Brain Tumors
Duke Principal Investigators: Dr. Scott Floyd and Dr. Zach Reitman
A Trial for Treatment of Cancer Patients With Multiple Brain Metastases Undergoing Whole-Brain Radiotherapy
e100377 MBM-BMX 001
Duke Principal Investigator: Dr. John Kirkpatrick
SRS Timing With Immune Checkpoint Inhibition in Patients With Untreated Brain Metastases From Non-small Cell Lung Cancer (STICk-IM-NSCLC)
e106340 IO and SRS Timing
Duke Principal Investigator: Dr. Scott Floyd
Quantitative MRI for Functional Assessment Following SBRT for Spinal Metastases
e103960 SBRT Spine MRI
Duke Principal Investigator: Dr. Scott Floyd
MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases
e103163 SRS MRI LITT
Duke Principal Investigator: Dr. Scott Floyd
Testing the Addition of an Anti-cancer Drug, BAY 1895344, With Radiation Therapy to the Usual Pembrolizumab Treatment for Recurrent Head and Neck Cancer
e107885 BAY 1895344 for Recurrent H/N Cancer
Duke Principal Investigator: Dr. Yvonne Mowery
Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx
e105899 H/N PET Dose De-escalation
Duke Principal Investigator: Dr. David Brizel
Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
e89619 Adaptive PET II
Duke Principal Investigator: Dr. Junzo Chino
Phase 2b Study of GC4711 in Combination With SBRT for Nonmetastatic Pancreatic Cancer
e107456 GRECO-2: GC4711 + SBRT for pancreatic cancer
Duke Principal Investigator: Dr. Manisha Palta
Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients
e89525 PROVE-HCC
Duke Principal Investigator: Dr. Manisha Palta
Noninvasive Assessment of Lymphedema Among Breast Cancer Survivors
e109917 Bullseye ultrasound for lymphedema measurement
Duke Principal Investigator: Dr. Susan McDuff
Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma (DLBCL)
e100510 DLBCL II
Duke Principal Investigator: Dr. Christopher Kelsey
Phase 1/2 Study of SBRT With or Without GC4711 for NSCLC
e106862 Galera Lung GTI-4711-201
Duke Principal Investigator: Dr. Christopher Kelsey
Groningen International Study on Sentinel Nodes in Vulvar Cancer-III (GROINSS-VIII)
e109439 NRG-GY024 Vulvar Cancer
Role of Ablative Radiotherapy in the Management of Metastatic Disease: A Patient Data Registry
e103137 Oligomets – Registry Study
Duke Principal Investigator: Dr. Joseph Salama