The Lafata Laboratory focuses on the theory, development and application of computational oncology. The lab interrogates disease at different length-scales of its biological organization via high-performance computing, multiscale modeling, advanced imaging technology and the applied analysis of stochastic partial differential equations. Current research interests include tumor topology, cellular dynamics, tumor immune microenvironment, drivers of radiation resistance and immune dysregulation, molecular insight into tissue heterogeneity and biologically-guided adaptative treatment strategies.

Kyle Lafata, PhD, is the Thaddeus V. Samulski Associate Professor at Duke University with faculty appointments in Radiation Oncology, Radiology, Pathology, Medical Physics and Electrical & Computer Engineering. He joined the faculty at Duke in 2020 following postdoctoral training at the US Department of Veterans Affairs. His dissertation work focused on the applied analysis of stochastic partial differential equations and high-dimensional image phenotyping, where he developed physics-based computational methods and soft-computing paradigms to interrogate images. These included stochastic modeling, self-organization and quantum machine learning (i.e., an emerging branch of research that explores the methodological and structural similarities between quantum systems and learning systems). Dr. Lafata has worked in various areas of computational medicine and biology, resulting in over 55 academic papers, 20 invited talks and more than 60 national conference presentations.

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