Radiation Injury, Regeneration and Carcinogenesis
The overall goal of the Lee lab’s research program is to improve the survivorship of cancer patients by minimizing acute and long-term side effects of radiation therapy. We are also investigating novel medical countermeasures against acute radiation syndrome in the scenarios of nuclear terrorism.
Current Research Interests
Utilizing sophisticated mouse models, we aim to study 1) critical signaling pathways that regulate the regeneration of normal tissues following radiation injury; 2) cell-autonomous and non-cell-autonomous mechanisms underlying the development of radiation-induced cancer.
- Radiation-induced hematologic malignancies and clonal hematopoiesis
- Radiation-induced acute and chronic intestinal injury
- Radiation response of rectal cancer (collaboration with Jatin Roper, MD)