Selected High-Impact DCBSM-Related Research Studies

Drs. Floyd, Mullikin and Reitman talking in clinic

High Impact Primary Research Studies – Duke Led

  1. Kirkpatrick JP, Wang Z, Sampson JH, McSherry F, Herndon JE 2nd, Allen KJ, Duffy E, Hoang JK, Chang Z, Yoo DS, Kelsey CR, Yin FF. Defining the Optimal Planning Target Volume in Image-Guided Stereotactic Radiosurgery of Brain Metastases: Results of a Randomized Trial. Int J Radiat Oncol Biol Phys 2015;91:100-108. doi: 10.1016/j.ijrobp.2014.09.004. Epub 2014 Oct 21. PMID: 25442342.
  2. Sperduto PW, De B, Li J, Carpenter D, Kirkpatrick J, Milligan M, Shih HA, Kutuk T, Kotecha R, Higaki H, Otsuka M, Aoyama H, Bourgoin M, Roberge D, Dajani S, Sachdev S, Gainey J, Buatti JM, Breen W, Brown PD, Ni L, Braunstein S, Gallitto M, Wang TJC, Shanley R, Lou E, Shiao J, Gaspar LE, Tanabe S, Nakano T, An Y, Chiang V, Zeng L, Soliman H, Elhalawani H, Cagney D, Thomas E, Boggs DH, Ahluwalia MS, Mehta MP. Graded Prognostic Assessment (GPA) for Patients With Lung Cancer and Brain Metastases: Initial Report of the Small Cell Lung Cancer GPA and Update of the Non-Small Cell Lung Cancer GPA Including the Effect of Programmed Death Ligand 1 and Other Prognostic Factors. Int J Radiat Oncol Biol Phys. 2022 Sep 1;114(1):60-74. doi: 10.1016/j.ijrobp.2022.03.020. Epub 2022 Mar 21. PMID: 35331827; PMCID: PMC9378572.
  3. Vaios EJ, Shenker RF, Hendrickson PG, Wan Z, Niedzwiecki D, Carpenter D, Floyd W, Winter SF, Shih HA, Dietrich J, Wang C, Salama AKS, Clarke JM, Allen K, Sperduto P, Mullikin T, Kirkpatrick JP, Floyd SR, Reitman ZJ. Symptomatic Necrosis With Dual Immune-Checkpoint Inhibition and Radiosurgery for Brain Metastases. JAMA Netw Open. 2025 Apr 1;8(4):e254347. doi: 10.1001/jamanetworkopen.2025.4347. PMID: 40202761; PMCID: PMC11983232.
  4. Vaios EJ, Shenker RF, Hendrickson PG, Wan Z, Niedzwiecki D, Winter SF, Shih HA, Dietrich J, Wang C, Salama AKS, Clarke JM, Allen K, Sperduto P, Mullikin T, Kirkpatrick JP, Floyd SR, Reitman ZJ. Long-Term Intracranial Outcomes With Combination Dual Immune-Checkpoint Blockade and Stereotactic Radiosurgery in Patients With Melanoma and Non-Small Cell Lung Cancer Brain Metastases. Int J Radiat Oncol Biol Phys. 2024 Apr 1;118(5):1507-1518. doi: 10.1016/j.ijrobp.2023.12.002. Epub 2023 Dec 12. PMID: 38097090; PMCID: PMC11056239.
  5. Sperduto PW, Marqueen KE, Chang E, Li J, Davies MA, Ebner DK, Breen WG, Lamba N, Shih HA, Edwards D, Kim MM, Mahal A, Rahman R, Ankrah N, Boggs DH, Lewis C, Hyer D, Buatti JM, Johri F, Soliman H, Masucci L, Roberge D, Aneja S, Chiang V, Phuong C, Braunstein S, Dajani S, Sachdev S, Wan Z, Niedzwiecki D, Vaios E, Kirkpatrick JP, Pasetsky J, Wang TJC, Kutuk T, Kotecha R, Ross RB, Rusthoven CG, Nakano T, Tawbi HA, Mehta MP. Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment. J Clin Oncol. 2025 Apr 17:JCO2401351. doi: 10.1200/JCO-24-01351. Epub ahead of print. PMID: 40245362.
  6. Zhao J, Vaios E, Wang Y, Yang Z, Cui Y, Reitman ZJ, Lafata KJ, Fecci P, Kirkpatrick J, Fang Yin F, Floyd S, Wang C. Dose-Incorporated Deep Ensemble Learning for Improving Brain Metastasis Stereotactic Radiosurgery Outcome Prediction. Int J Radiat Oncol Biol Phys. 2024 Oct 1;120(2):603-613. doi: 10.1016/j.ijrobp.2024.04.006. Epub 2024 Apr 12. PMID: 38615888.
  7. Narloch JL, Farber SH, Sammons S, McSherry F, Herndon JE, Hoang JK, Yin FF, Sampson JH, Fecci PE, Blackwell KL, Kirkpatrick JP, Kim GJ. Biopsy of Enlarging Lesions after Stereotactic Radiosurgery for Brain Metastases frequently Reveals Radiation Necrosis. Neuro-Oncology. 2017;19(10):1391-1397. doi: 10.1093/neuonc/nox090. PMID: 28472527.
  8. Kim GJ, Buckley ED, Herndon JE, Allen KJ, Dale TS, Adamson JD, Lay L, Giles WM, Rodrigues AE, Wang Z, Kelsey CR, Torok JA Jr, Chino JP, Fecci PE, Sampson JH, Anders CK, Floyd SR, Yin FF, Kirkpatrick JP. Outcomes in Patients with 4-10 Brain Metastases Treated with Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study. Adv Radiat Oncol. 2021 Jul 23;6(6):100760. doi: 10.1016/j.adro.2021.100760. PMID: 34934856
  9. Carpenter DJ, Fairchild AT, Adamson JD, Fecci PE, Sampson JH, Herndon JE, Torok JA, Mullikin TC, Kim GJ, Reitman ZJ, Kirkpatrick JP, Floyd SR. Outcomes in Patients with Intact and Resected Brain Metastasis Treated with 5-Fraction Stereotactic Radiosurgery. Adv Radiat Oncol. 2022 Dec 29;8(2):101166. doi: 10.1016/j.adro.2022.101166. PMID: 36845614; PMCID: PMC9943776.
  10. Natesan D, Carpenter DJ, Giles W, Oyekunle T, Niedzwiecki D, Reitman ZJ, Kirkpatrick JP, Floyd SR. Clinical Factors Associated With 30-Day Mortality Among Patients Undergoing Radiation Therapy for Brain Metastases. Adv Radiat Oncol. 2023 Mar 8;8(4):101211. doi: 10.1016/j.adro.2023.101211. PMID: 37152484; PMCID: PMC10157109.

 

High-Impact Non-Primary Research Studies – Duke Led

  1. Moravan MJ, Fecci PE, Anders CK, Clarke JM, Salama AKS, Adamson JD, Floyd SR, Torok JA, Salama JK, Sampson JH, Sperduto PW, Kirkpatrick JP. Current multidisciplinary management of brain metastases. Cancer. 2020 Apr 1;126(7):1390-1406. doi: 10.1002/cncr.32714. Epub 2020 Jan 23. PMID: 31971613.
  2. Kirkpatrick JP, Soltys SG, Lo SS, Beal K, Shrieve DC, Brown PD. The radiosurgery fractionation quandary: single fraction or hypofractionation? Neuro Oncol. 2017 Apr 1;19(suppl_2):ii38-ii49. doi: 10.1093/neuonc/now301. PMID: 28380634; PMCID: PMC5463582.
  3. Kirkpatrick JP, Laack NN, Soltys SG, Halasz LM, Breneman JC, Shih HA. Brain Metastases From Melanoma: Therapy at the Crossroads. Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):713-716. doi: 10.1016/j.ijrobp.2016.06.005. PMID: 27788943.
  4. Minniti G, Soltys SG, Halasz LM, Breneman JC, Chan M, Laack NN, Kirkpatrick JP. Stereotactic Radiosurgery for Resected Brain Metastases: New Evidence Supports a Practice Shift, but Questions Remain. Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):535-538. doi: 10.1016/j.ijrobp.2017.08.024. PMID: 29413262.
  5. Fecci PE, Champion CD, Hoj J, McKernan CM, Goodwin CR, Kirkpatrick JP, Anders CK, Pendergast AM, Sampson JH. The Evolving Modern Management of Brain Metastasis. Clin Cancer Res. 2019 Nov 15;25(22):6570-6580. doi: 10.1158/1078-0432.CCR-18-1624. Epub 2019 Jun 18. PMID: 31213459; PMCID: PMC8258430.
  6. Kirkpatrick JP, Laack NN, Halasz LM, Minniti G, Chan MD. Proton Therapy for Brain Metastases: A Question of Value. Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):830-832. doi: 10.1016/j.ijrobp.2018.05.005. Epub 2018 Jun 20. PMID: 29976495.
  7. Salama JK, Kirkpatrick JP, Yin FF. Stereotactic body radiotherapy treatment of extracranial metastases. Nat Rev Clin Oncol. 2012 Nov;9(11):654-65. doi: 10.1038/nrclinonc.2012.166. Epub 2012 Sep 25. PMID: 23007273.
  8. Kirkpatrick JP, van der Kogel AJ, Schultheiss TE. Radiation dose-volume effects in the spinal cord. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S42-9. doi: 10.1016/j.ijrobp.2009.04.095. PMID: 20171517.

 

Other – High-Impact Non-Duke Led Studies

  1. Voigtlaender S, Nelson T, Karschnia P, Vaios E, Kim M, Lohmann P, Galldiks N, Filbin M, Azizi S, Natarajan V, Monje M, Dietrich J, Winter. Value of Artificial Intelligence in Neuro-Oncology. The Lancet Digital Health. 2025, April 4. [In Press]
  2. Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP. Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). JAMA Oncol. 2017 Jun 1;3(6):827-831. doi: 10.1001/jamaoncol.2016.3834. PMID: 27892978; PMCID: PMC5824323.
  3. Soliman H, Ruschin M, Angelov L, Brown PD, Chiang VLS, Kirkpatrick JP, Lo SS, Mahajan A, Oh KS, Sheehan JP, Soltys SG, Sahgal A. Consensus Contouring Guidelines for Postoperative Completely Resected Cavity Stereotactic Radiosurgery for Brain Metastases. Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):436-442. doi: 10.1016/j.ijrobp.2017.09.047. Epub 2017 Oct 4. PMID: 29157748.
  4. Weller M, Remon J, Rieken S, Vollmuth P, Ahn MJ, Minniti G, Le Rhun E, Westphal M, Brastianos PK, Soo RA, Kirkpatrick JP, Goldberg SB, Öhrling K, Hegi-Johnson F, Hendriks LEL. Central nervous system metastases in advanced non-small cell lung cancer: A review of the therapeutic landscape. Cancer Treat Rev. 2024 Nov;130:102807. doi: 10.1016/j.ctrv.2024.102807. Epub 2024 Aug 2. PMID: 39151281.